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24-27 November 2022
Karlsruhe Institute of Technology
Europe/Berlin timezone

Deciphering a smart material – a new method to measure actin cortex mechanics and mechanosensitivity

26 Nov 2022, 14:00
Otto-Lehmann Hörsaal (KIT Campus South)

Otto-Lehmann Hörsaal

KIT Campus South

KIT Campus map: Building: 30.22 Room: 022 Address: Institute of Technology, Engesserstraße 7, 76131 Karlsruhe Coordinates: 49.01244, 8.41062
Talk Physics talks Keynote Physics Talks 4


Mrs. Elisabeth Fischer-Friedrich (Excellence Cluster Physics of Life, TU Dresden)


The actin cortex is a thin polymer network beneath the plasma membrane in animal cells. It acts as a mechanical shield of the cell and as a major regulator of cell shape and cell migration. The actin cortex is a complex material with time-dependent viscoelastic mechanical properties. It is further subject to a self-generated active contractile stress and to constituent turnover. I will discuss our measurement results on frequency-dependent cortical viscoelasticity measured by atomic force microscopy. In addition, I will discuss how mechanosensitivity of molecular bonds can affect molecular composition of the cortex and how this mechanosensitivity can be quantified in live cells.

Category Other

Primary author

Mrs. Elisabeth Fischer-Friedrich (Excellence Cluster Physics of Life, TU Dresden)

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