Synchrotron-based X-ray imaging of biological samples is often hindered by the radiation dose deployed in the sample, in particular for in vivo imaging and at μm-resolution. Many efforts have been made to reduce the dose, e.g., by propagation-based phase contrast imaging at high photon energies (~30 keV) [1, 2]. However, the detection efficiency of indirectly converting, scintillator-based...
$Ca^{2+}$ diffusion within cells and penetration of $Ca^{2+}$ through their membrane engages a wide field of theoretical and experimental research. Therefore, the monitoring of rapid changes of the $Ca^{2+}$ concentration beneath the cell membrane is of great interest. Here, we make use of BK-type $Ca^{2+}$-activated $K^+$ channels to determine the $Ca^{2+}$ activity of PMCA, which transport...
The ability of many animal species to orient themselves during long distance journeys around the globe is a fascinating topic. Althoughit has been known for decades that many of these species can sense the geomagnetic field and to use it as a navigation aid, the underlying sensory mechanisms are still poorly understood. One hypothesis is that magnetic particles might be part of such a sensor....
The complex hierarchical structure of bone undergoes a lifelong remodeling process, where it adapts to mechanical needs. Hereby, bone resorption by osteoclasts and bone formation by osteoblasts have to be balanced to sustain a healthy and stable organ. Osteocytes orchestrate this interplay by sensing mechanical strains and translating them into biochemical signals.
The osteocytes are located...
